What is prednisolone and what is it prescribed for?
Prednisolone is a steroid that prevents the release of chemicals in the body that cause inflammation.
Prednisolone is used to treat many different inflammatory conditions such as lupus, psoriasis, arthritis, intestinal ulcers, allergic disorders, glandular disorders and conditions that affect the skin, eyes, lungs, stomach, nervous system or blood cells.
Prednisolone Tablet Brands
Deltacortril, Deltastab, Dilacort and Pevanti.
Important note about prednisolone
People with fungal infections in any part of the body should not use this medicine.
Before taking prednisolone, know that:
This drug weakens the immune system and thus puts you at greater risk of infection.
Steroids can also make the infection worse or reactivate it, so be sure to talk to your doctor about your past illness or infection before taking it.
Tell your doctor if you have any of the following:
Herpes eye infection
Intestinal and gastric ulcers
High blood pressure
Muscle disorders such as muscle weakness
Also, inform your doctor about diseases such , both now and in the past.
Steroid drugs can increase a person’s glucose or blood sugar or urine, and therefore the doctor may make changes in the dose of the drug in these conditions.
Prednisolone use during pregnancy and lactation
It is not yet clear whether this drug is also harmful to the fetus.
Tell your doctor if you are pregnant or planning to become pregnant.
It is also unclear whether prednisolone can pass into breast milk and affect the baby.
Be sure to tell your doctor if you are breastfeeding.
Taking prednisolone for children
Prednisolone should not be used in children under 3 years of age. Its consumption in children reduces growth.
In children over three years of age, this drug should be taken in low doses under a doctor’s supervision.
The best time to take prednisolone tablets and how to take it
If prednisolone is prescribed once a day, take it in the morning after breakfast.
Take prednisolone with or after food to reduce gastrointestinal side effects.
Take enteric coated tablets before or after meals and do not chew or crush them.
If you are taking this pill at the same time as stomach medications and antacids, there should be at least 2 hours between them.
How should prednisolone be used?
You should follow the instructions on the medicine label:
Your doctor can also change the dose on these labels and never lower or lower the dose of this medicine on your head.
This medicine is sometimes given every other day.
The dose of liquid medicine is usually measured with a medicine spoon or cup.
If you do not have these measuring spoons, be sure to get one from a pharmacy.
You should shake the medicine well before measuring the dose. Then follow the instructions on the label.
For all kinds of pills, you have to open the box or can with a dry hand and take it out of the foil.
If you have difficulty swallowing, use the syrup.
You should change the dose if you have problems such as a serious illness, fever, surgery or infection.
You should not stop taking this medicine suddenly.
You should take each medicine on time because a bit of delay can change the result of this medicine or delay the treatment.
If people have surgery, your doctor may stop taking this medicine for a short time.
This medicine should be stored at room temperature away from moisture and heat.
Mechanism of action of prednisolone
The drug crosses the cell membrane and binds to its receptors in the cytoplasm, and the receptor drug complex enters the cell nucleus.
This complex binds to specific regions of DNA and stimulates the mRNA transcription process, then the enzymes that are responsible for the systemic effects of corticosteroids are made.
The effect of corticosteroids on inflammation is that they prevent the accumulation of inflammatory cells in the area of inflammation and inhibit phagocytosis and release chemical mediators of inflammation.
Pharmacokinetics of prednisolone
The half-life of the drug is two to three hours and the bioavailability of the drug is about 90-80%.
Prednisolone is converted in the liver and inactive metabolites. Excretion of metabolites is via the kidneys.
What to do if you forget to use prednisolone?
In these cases, never do it yourself and call your doctor.
What happens if this drug is overdosed?
Overdosing of this drug is not considered a threat to life.
However, long-term use of high-steroid medications can cause symptoms such as thinning of the skin, bruising, changes in the shape or location of body fat, especially on the face, neck, back, acne and facial hair, menstrual problems, impotence Men and sexual reluctance to follow.
What should I avoid while taking this medicine?
You should not get the live vaccine while taking prednisolone.
This vaccine does not work well while taking this medicine and does not protect you from the disease, so you should avoid approaching sick and infected people.
Side effects of prednisolone
See your doctor if you notice any allergy symptoms, including:
Shortness of breath even in mild, swollen, rapid weight gain.
Bruising, thinning of the skin or any wound that does not heal.
Severe depression, changes in personality, unreasonable thoughts and behavior.
New or unusual pain in the arm, leg and back.
Bloody or tarry stools, bloody coughs or vomits that look like coffee beans.
Severe upper abdominal pain, nausea and vomiting.
Muscle contraction, potassium deficiency, constipation, irregular heartbeat, chest pain, frequent urination, numbness or tingling.
Get angry fast.
Severe decrease in urine output
Change the mood
Difficulty talking, thinking and walking.
Darkening of the skin
Lack of appetite
Redness of the skin
Unexpected weight loss
Redness of the face
Steroids affect the growth of children.
Be sure to inform the doctor about the improper and low growth of the child in this situation.
Other common side effects include the following:
Swelling of hands and feet.
Changes in menstruation.
Muscle pain and weakness.
Stomach problems and bloating.
What other medications can affect the process and effectiveness of prednisolone?
Medications that react with prednisolone include vitamins and plant products.
Concomitant use of prednisolone with anticoagulants reduces the effects of these drugs.
Concomitant use of prednisolone with barbiturates, ephedrine and phenytoin increases the clearance of hydrocortisone.
Concomitant use of prednisolone with estrogen enhances the effect of hydrocortisone.
Concomitant use of prednisolone with ketoconazole and macrolide antibiotics may reduce the clearance of hydrocortisone.
Concomitant use of prednisolone with NSAIDs may increase the gastrointestinal side effects of the drug.
Concomitant use of prednisolone with amphotericin B, carbonicillin, pipracillin, t-carcillin, or diuretics may cause severe hypokalemia.
Concomitant use of prednisolone with cardiac glycosides increases cardiac glycoside intoxication.
Concomitant use of prednisolone with insulin increases the need for insulin.
So inform your doctor about any medication you are taking now and in the past.
Taking this drug may interfere with tests of the hypothalamic-pituitary-adrenal axis.
This drug increases osteoporosis and high blood pressure in the elderly and postmenopausal women.
Administration of values above 5.7 mg / day causes symptoms similar to Cushing’s syndrome.
Avoid abrupt discontinuation of the drug after prolonged use.
Limit sodium intake during treatment.
Ophthalmologic examinations should be performed regularly during long-term treatment.
Prednisolone group drugs
Salmeterol + Fluticasone
Budesonide + Formmeterol